PDB | 7rpk Murine Dispatched
Cryo-EM structure of murine Dispatched in complex with Sonic hedgehog
label Keywords
rnd transporter, hedgehog binding, sterol sensing domain, sodium binding, membrane protein
event_note Published
11/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
CHOLESTEROL HEMISUCCINATE, Lauryl Maltose Neopentyl Glycol, SODIUM ION, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ZINC ION, SULFATE ION
Original publication
import_contacts Title
Dispatched uses Na + flux to power release of lipid-modified Hedgehog.
import_contacts Journal
Nature 2021
import_contacts DOI
10.1038/s41586-021-03996-0
person Authors
Beachy, P.A., Hatakeyama, J., Cheng, Y., Wang, Q., Mann, R.K., Ding, K., Ma, Y., Zhang, Y., Asarnow, D.E.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Beachy, P.A., Hatakeyama, J., Cheng, Y., Wang, Q., Mann, R.K., Ding, K., Ma, Y., Zhang, Y., Asarnow, D.E. , provided free of copyright via the Protein DataBank. View original data or read license terms.
