PDB | 7piv Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH
Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution.
label Keywords
gpcr, melanocortin-4 receptor, melanocortin receptors, setmelanotide, ndp-alpha-msh, alpha-18 msh, antagonism, agonism, appetite regulation, anti-obesity treatment, signaling protein
event_note Published
11/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
CALCIUM ION
Original publication
import_contacts Title
Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
import_contacts Journal
Cell Res. 2021
import_contacts DOI
10.1038/s41422-021-00569-8
person Authors
Szczepek, M., Kleinau, G., Koch, A., Burger, J., Schacherl, M., Kuhnen, P., Kwiatkowski, D., Scheerer, P., Schmidt, A., Beck-Sickinger, A.G., Hildebrand, P.W., Hilger, D., Spahn, C.M.T., Mielke, T., Hilal, T., Heyder, N.A., Kobilka, B.K., Gallandi, M., Bauer, B., Biebermann, H., Paisdzior, S., Speck, D.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Szczepek, M., Kleinau, G., Koch, A., Burger, J., Schacherl, M., Kuhnen, P., Kwiatkowski, D., Scheerer, P., Schmidt, A., Beck-Sickinger, A.G., Hildebrand, P.W., Hilger, D., Spahn, C.M.T., Mielke, T., Hilal, T., Heyder, N.A., Kobilka, B.K., Gallandi, M., Bauer, B., Biebermann, H., Paisdzior, S., Speck, D. , provided free of copyright via the Protein DataBank. View original data or read license terms.
