PDB | 7nre E.coli BamA beta-barrel
Crystal structure of E.coli BamA beta-barrel in complex with darobactin (crystal form 1)
label Keywords
beta-barrel, outer membrane, protein insertion, protein folding, protein maturation, antibiotic, natural product, cyclized peptide, membrane protein
event_note Published
01/31/2024
blur_on Resolution
2.3 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, MAGNESIUM ION
Original publication
import_contacts Title
The antibiotic darobactin mimics a beta-strand to inhibit outer membrane insertase.
import_contacts Journal
Nature 2021
import_contacts DOI
10.1038/s41586-021-03455-w
person Authors
Maier, T., Marzinek, J.K., Bolla, J.R., Kaur, H., Jakob, R.P., Hiller, S., Lewis, K., Bond, P.J., Green, R., Robinson, C.V., Imai, Y., Agustoni, E.
copyrightData provided by Research Collaboration for Structural Biology, Maier, T., Marzinek, J.K., Bolla, J.R., Kaur, H., Jakob, R.P., Hiller, S., Lewis, K., Bond, P.J., Green, R., Robinson, C.V., Imai, Y., Agustoni, E. , provided free of copyright via the Protein DataBank. View original data or read license terms.
