PDB | 7mjs Major Facilitator Superfamily Domain containing 2A

Single-Particle Cryo-EM Structure of Major Facilitator Superfamily Domain containing 2A in complex with LPC-18:3

label Keywords
mfs transporters, lysolipids, blood-brain barrier, omega-3 fatty acids, lipid transport-immune system complex
event_note Published
11/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl] (9~{Z},12~{Z},15~{Z})-octadeca-9,12,15-trienoate, 2-acetamido-2-deoxy-beta-D-glucopyranose

Original publication

import_contacts Title
Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
import_contacts Journal
Nature 2021
import_contacts DOI
10.1038/s41586-021-03650-9
person Authors
Quek, D.Q.Y., Khelashvili, G., Wong, B.H., Marty, M.T., Keener, J.E., Mancia, F., Clarke, O.B., Chua, G.L., Silver, D.L., Kossiakoff, A.A., Pepe, J.G., Parisi, G., Choy, B.C., Chin, C.F., Erramilli, S.K., Kloss, B., Cater, R.J., Tokarz, P.

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