PDB | 7m19 SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2)
SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2)
label Keywords
ion channel, inhibitor, membrane protein
event_note Published
03/12/2021
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid
Original publication
import_contacts Title
Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
import_contacts Journal
Nat Commun 2022
import_contacts DOI
10.1038/s41467-022-28435-0
person Authors
Sheldon, R.D., Nau, P., Zhang, Y., Taylor, E.B., Chheda, P.R., Kerns, R., Gunasekar, S.K., Samuel, I., Gerber, E.E., Kumar, A., Hong, J., Grzesik, W.J., Xie, L., Sah, R., Maurer, J., Klein, S., Beals, J.W., Kulkarni, C.A., Kang, C., Norris, A.W., Key, P., Imai, Y., My-Ta, C., Smith, J.K., Lerner, D.J., Heebink, J., Elliot-Hudson, M., Brohawn, S.G., Kern, D.M., Smith, G.I.
copyrightData provided by Research Collaboration for Structural Biology, Sheldon, R.D., Nau, P., Zhang, Y., Taylor, E.B., Chheda, P.R., Kerns, R., Gunasekar, S.K., Samuel, I., Gerber, E.E., Kumar, A., Hong, J., Grzesik, W.J., Xie, L., Sah, R., Maurer, J., Klein, S., Beals, J.W., Kulkarni, C.A., Kang, C., Norris, A.W., Key, P., Imai, Y., My-Ta, C., Smith, J.K., Lerner, D.J., Heebink, J., Elliot-Hudson, M., Brohawn, S.G., Kern, D.M., Smith, G.I. , provided free of copyright via the Protein DataBank. View original data or read license terms.
