PDB | 7lwd Wild-type human serotonin transporter complexed
Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab
label Keywords
antidepressant, complex, transporter, antibody, transport protein, transport protein-immune system complex
event_note Published
10/23/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose
Original publication
import_contacts Title
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
import_contacts Journal
Nat Commun 2021
import_contacts DOI
10.1038/s41467-021-25363-3
person Authors
Laursen, L., Coleman, J.A., Loland, C.J., Newman, A.H., Kalenderoglou, I.E., Plenge, P., Gouaux, E., Yang, D., Salomon, K.
copyrightData provided by Research Collaboration for Structural Biology, Laursen, L., Coleman, J.A., Loland, C.J., Newman, A.H., Kalenderoglou, I.E., Plenge, P., Gouaux, E., Yang, D., Salomon, K. , provided free of copyright via the Protein DataBank. View original data or read license terms.
