PDB | 7ld3 Human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist and an allosteric ligand
label Keywords
signaling protein, membrane protein, active-state g protein-coupled receptor, adenosine a1 receptor, pam, allosteric modulator
event_note Published
11/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
ADENOSINE, {2-amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone
Original publication
import_contacts Title
Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia.
import_contacts Journal
Nature 2021
import_contacts DOI
10.1038/s41586-021-03897-2
person Authors
Miao, Y., Glukhova, A., Valant, C., Panel, N., Thal, D.M., Carlsson, J., Sexton, P.M., O'Sullivan, K., Venugopal, H., May, L.T., Chia, L.Y., Scammells, P., Christie, M.J., Cowie-Kent, I., Draper-Joyce, C.J., White, P.J., Nguyen, A.T.N., Wang, J., Imlach, W.L., Wootten, D., Danev, R., Bhola, R., Bhattarai, A., Christopoulos, A.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Miao, Y., Glukhova, A., Valant, C., Panel, N., Thal, D.M., Carlsson, J., Sexton, P.M., O'Sullivan, K., Venugopal, H., May, L.T., Chia, L.Y., Scammells, P., Christie, M.J., Cowie-Kent, I., Draper-Joyce, C.J., White, P.J., Nguyen, A.T.N., Wang, J., Imlach, W.L., Wootten, D., Danev, R., Bhola, R., Bhattarai, A., Christopoulos, A. , provided free of copyright via the Protein DataBank. View original data or read license terms.
