PDB | 7k65 Hedgehog receptor Patched (PTCH1)
Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23
label Keywords
membrane protein
event_note Published
11/20/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta,17beta,25R)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside
Original publication
import_contacts Title
Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.
import_contacts Journal
Proc.Natl.Acad.Sci.USA 2020
import_contacts DOI
10.1073/pnas.2011560117
person Authors
Beachy, P.A., Liang, J., Bulkley, D.P., Lu, W.J., Cheng, Y., Zhang, Y., Ralko, A., Han, S., Cho, W., Li, A., Manglik, A., Roberts, K.J.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Beachy, P.A., Liang, J., Bulkley, D.P., Lu, W.J., Cheng, Y., Zhang, Y., Ralko, A., Han, S., Cho, W., Li, A., Manglik, A., Roberts, K.J. , provided free of copyright via the Protein DataBank. View original data or read license terms.
