PDB | 7evy Siponimod -bound Sphingosine-1-phosphate receptor 1

Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein

label Keywords
homo sapiens, membrane protein
event_note Published
07/02/2025
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose

Original publication

import_contacts Title
Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition.
import_contacts Journal
Cell Res. 2021
import_contacts DOI
10.1038/s41422-021-00566-x
person Authors
Yang, S., Li, Z., Yuan, Y., Yan, W., Shao, Z., Su, Z., Luo, K., Cheng, L., Wu, C., Wang, W., Jia, G., Li, Q.

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