PDB | 7d92 Na+,K+-ATPase in the E2P state
Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ and anthroylouabain (P4(3)2(1)2 symmetry)
label Keywords
na+, k+-atpase, membrane protein, ion transport, cardiotonic steroids, transport protein
event_note Published
11/13/2024
blur_on Resolution
3.9 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
MAGNESIUM ION, CHOLESTEROL, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, [(2~{R},3~{R},4~{R},5~{S},6~{S})-2-[[(1~{R},3~{S},5~{S},8~{R},9~{S},10~{R},11~{R},13~{R},14~{S},17~{R})-10-(hydroxymethyl)-13-methyl-1,5,11,14-tetrakis(oxidanyl)-17-(5-oxidanylidene-2~{H}-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1~{H}-cyclopenta[a]phenanthren-3-yl]oxy]-6-methyl-3,5-bis(oxidanyl)oxan-4-yl] anthracene-9-carboxylate, 2-acetamido-2-deoxy-beta-D-glucopyranose
Original publication
import_contacts Title
Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state.
import_contacts Journal
Proc.Natl.Acad.Sci.USA 2021
import_contacts DOI
10.1073/pnas.2020438118
person Authors
Cornelius, F., Vilsen, B., Motoyama, K., Ogawa, H., Kanai, R., Toyoshima, C.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Cornelius, F., Vilsen, B., Motoyama, K., Ogawa, H., Kanai, R., Toyoshima, C. , provided free of copyright via the Protein DataBank. View original data or read license terms.
