PDB | 7cko Human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate 7ACC2 in the inward-open conformation
Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate 7ACC2 in the inward-open conformation
label Keywords
proton-coupled monocarboxylate transporter, mct1, basigin, azd3965, single particle cryo-em, latate transporter, transport protein
event_note Published
03/27/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
7-[methyl-(phenylmethyl)amino]-2-oxidanylidene-chromene-3-carboxylic acid
Original publication
import_contacts Title
Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
import_contacts Journal
Cell 2021
import_contacts DOI
10.1016/j.cell.2020.11.043
person Authors
Yuan, Y., Zhu, A., Lei, J., Yan, C., Xu, H., Jiang, X., Zhang, S., Wang, N.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Yuan, Y., Zhu, A., Lei, J., Yan, C., Xu, H., Jiang, X., Zhang, S., Wang, N. , provided free of copyright via the Protein DataBank. View original data or read license terms.
