PDB | 7bc7 Proton coupled folate transporter at pH 6.0 bound to pemetrexed
Cryo-EM structure of the proton coupled folate transporter at pH 6.0 bound to pemetrexed
label Keywords
transporter folate proton symporter, membrane protein
event_note Published
07/02/2025
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID
Original publication
import_contacts Title
Structural basis of antifolate recognition and transport by PCFT.
import_contacts Journal
Nature 2021
import_contacts DOI
10.1038/s41586-021-03579-z
person Authors
Lea, S.M., Biggin, P.C., Deme, J.C., Newstead, S., Owens, R.J., Parker, J.L., Huo, J., Goldman, I.D., Kuteyi, G., Wu, Z.
copyrightData provided by Research Collaboration for Structural Biology, Lea, S.M., Biggin, P.C., Deme, J.C., Newstead, S., Owens, R.J., Parker, J.L., Huo, J., Goldman, I.D., Kuteyi, G., Wu, Z. , provided free of copyright via the Protein DataBank. View original data or read license terms.
