PDB | 7awn Structure of the thermostabilized EAAT1 cryst mutant

Structure of the thermostabilized EAAT1 cryst mutant in complex with rubidium and barium and the allosteric inhibitor UCPH101

label Keywords
excitatory amino acid transporter 1, human glutamate transporter, slc1a3, ion-coupling mechanism, membrane protein
event_note Published
01/31/2024
blur_on Resolution
3.92 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile, BARIUM ION, RUBIDIUM ION

Original publication

import_contacts Title
The ion-coupling mechanism of human excitatory amino acid transporters.
import_contacts Journal
Embo J. 2022
import_contacts DOI
10.15252/embj.2021108341
person Authors
Assal, R., Dhenin, J., Kumar, A., Chamot-Rooke, J., Legrand, P., Rey, M., Canul-Tec, J.C., Reyes, N.

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