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      PDB | 7a69 Nanodisc reconstituted human ABCB1

      Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine

      label Keywords
      p-glycoprotein, mdr1, nanodisc, transport protein
      event_note Published
      07/02/2025
      filter_center_focus Method
      ELECTRON MICROSCOPY
      add_circle Ligands
      vincristine, CHOLESTEROL

      Original publication

      import_contacts Title
      Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
      import_contacts Journal
      Proc.Natl.Acad.Sci.USA 2020
      import_contacts DOI
      10.1073/pnas.2010264117
      person Authors
      Irobalieva, R.N., Locher, K.P., Alam, A., Nosol, K., Romane, K., Kowal, J., Fujita, N.

      Read article from Proc.Natl.Acad.Sci.USA

      copyrightData provided by Research Collaboration for Structural Biology, Irobalieva, R.N., Locher, K.P., Alam, A., Nosol, K., Romane, K., Kowal, J., Fujita, N. , provided free of copyright via the Protein DataBank. View original data or read license terms.

      Simulations available

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