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      PDB | 6zg4 Structure of M1-StaR-T4L

      Structure of M1-StaR-T4L in complex with HTL0009936 at 2.35A

      label Keywords
      gpcr, 7tm, membrane protein
      event_note Published
      10/16/2024
      blur_on Resolution
      2.33 Å
      filter_center_focus Method
      X-RAY DIFFRACTION
      add_circle Ligands
      ethyl (4~{S})-4-[4-[(1-methylcyclobutyl)carbamoyl]piperidin-1-yl]azepane-1-carboxylate, OLEIC ACID, TRIETHYLENE GLYCOL, PHOSPHATE ION

      Original publication

      import_contacts Title
      From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
      import_contacts Journal
      Cell 2021
      import_contacts DOI
      10.1016/j.cell.2021.11.001
      person Authors
      Weir, M., Warneck, J., Broad, L.M., Browning, M., Jazayeri, A., Errey, J.C., Rucktooa, P., Deakin, J.F.W., Dwomoh, L., Brown, G.A., Brown, J., Pickworth, M., Tehan, B.G., Sexton, P.M., Dawson, G.R., Patel, J.C., Liptrot, J., Teobald, B., Bundgaard, C., Hudson, B.D., Nathan, P.J., Tasker, T., Congreve, M.S., Brown, A.J.H., Dias, J.M., Bennett, K.A., Cross, D.M., Goonawardena, A.V., Shahabi, S., Vinson, M., Langmead, C.J., Cansfield, J.E., Perini, F., Bradley, S.J., Smith, R.T., Cooke, R.M., Osborne, G., Tobin, A.B., Hurrell, E., Mattedi, G., Molloy, C., Okrasa, K., Marshall, F.H., Phillips, K., Robertson, N., Christopoulos, A., Morairty, S.R., de Graaf, C.

      Read article from Cell

      Member of

      copyrightData provided by Research Collaboration for Structural Biology, Weir, M., Warneck, J., Broad, L.M., Browning, M., Jazayeri, A., Errey, J.C., Rucktooa, P., Deakin, J.F.W., Dwomoh, L., Brown, G.A., Brown, J., Pickworth, M., Tehan, B.G., Sexton, P.M., Dawson, G.R., Patel, J.C., Liptrot, J., Teobald, B., Bundgaard, C., Hudson, B.D., Nathan, P.J., Tasker, T., Congreve, M.S., Brown, A.J.H., Dias, J.M., Bennett, K.A., Cross, D.M., Goonawardena, A.V., Shahabi, S., Vinson, M., Langmead, C.J., Cansfield, J.E., Perini, F., Bradley, S.J., Smith, R.T., Cooke, R.M., Osborne, G., Tobin, A.B., Hurrell, E., Mattedi, G., Molloy, C., Okrasa, K., Marshall, F.H., Phillips, K., Robertson, N., Christopoulos, A., Morairty, S.R., de Graaf, C. , provided free of copyright via the Protein DataBank. View original data or read license terms.

      Simulations available

      play_circle_outline6zg4_default_dppc

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