PDB | 6zdv Stabilized A2A adenosine receptor A2AR-StaR2-bRIL
Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with Chromone 5d
label Keywords
g protein-coupled receptor, membrane protein, receptor, protein binding
event_note Published
10/23/2024
blur_on Resolution
2.13 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
[2-methyl-3-(4-methyl-1,3-thiazol-2-yl)-4-oxidanylidene-6-propyl-chromen-7-yl] ethanoate, SODIUM ION, CHOLESTEROL, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, OLEIC ACID, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Original publication
import_contacts Title
X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A 2A Adenosine Receptor Antagonists.
import_contacts Journal
Angew.Chem.Int.Ed.Engl. 2020
import_contacts DOI
10.1002/anie.202003788
person Authors
Aqvist, J., Cooke, R.M., Deflorian, F., Dore, A.S., Azuaje, J., Sotelo, E., Gutierrez-de-Teran, H., Jespers, W., Majellaro, M., Zhukov, A., Mason, J.S., Keranen, H., Garcia-Mera, X., Verdon, G., Congreve, M., de Graaf, C.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Aqvist, J., Cooke, R.M., Deflorian, F., Dore, A.S., Azuaje, J., Sotelo, E., Gutierrez-de-Teran, H., Jespers, W., Majellaro, M., Zhukov, A., Mason, J.S., Keranen, H., Garcia-Mera, X., Verdon, G., Congreve, M., de Graaf, C. , provided free of copyright via the Protein DataBank. View original data or read license terms.
