PDB | 6z10 Humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91)
Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist
label Keywords
g protein-coupled receptor gpcr succinate receptor, membrane protein
event_note Published
11/20/2024
blur_on Resolution
2.269 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
2-[2-[[3-[4-chloranyl-2-fluoranyl-5-[(3~{R})-piperidin-3-yl]oxy-phenyl]-2-fluoranyl-phenyl]carbonylamino]-5-fluoranyl-phenyl]ethanoic acid, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, SULFATE ION, CHLORIDE ION
Original publication
import_contacts Title
Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure.
import_contacts Journal
J.Med.Chem. 2020
import_contacts DOI
10.1021/acs.jmedchem.0c01020
person Authors
Schlapbach, A., Villard, F., Piller, F., Stringer, R., Wagner, T., Gommermann, N., Piechon, P., Kaupmann, K., Littlewood-Evans, A., Janser, P., Wilcken, R., Bouhelal, R., Fehlmann, D., Velcicky, J., Harlfinger, S., Haffke, M., Cotesta, S.
copyrightData provided by Research Collaboration for Structural Biology, Schlapbach, A., Villard, F., Piller, F., Stringer, R., Wagner, T., Gommermann, N., Piechon, P., Kaupmann, K., Littlewood-Evans, A., Janser, P., Wilcken, R., Bouhelal, R., Fehlmann, D., Velcicky, J., Harlfinger, S., Haffke, M., Cotesta, S. , provided free of copyright via the Protein DataBank. View original data or read license terms.
