PDB | 6x19 Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor
label Keywords
g-coupled protein receptor, gpcr, membrane protein, non-peptide agonist
event_note Published
10/30/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one
Original publication
import_contacts Title
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
import_contacts Journal
Mol.Cell 2020
import_contacts DOI
10.1016/j.molcel.2020.09.020
person Authors
Glukhova, A., Gloriam, D.E., Miller, L.J., Liang, Y.L., Furness, S.G.B., Sexton, P.M., Zhao, P., Reedtz-Runge, S., Venugopal, H., Zhang, X., Stewart, G.D., Langmead, C.J., Wootten, D., Egebjerg, T., Senel, P., Underwood, C.R., Ang, S.Y., Danev, R., Kooistra, A.J., Belousoff, M.J., Christopoulos, A., Truong, T.T.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Glukhova, A., Gloriam, D.E., Miller, L.J., Liang, Y.L., Furness, S.G.B., Sexton, P.M., Zhao, P., Reedtz-Runge, S., Venugopal, H., Zhang, X., Stewart, G.D., Langmead, C.J., Wootten, D., Egebjerg, T., Senel, P., Underwood, C.R., Ang, S.Y., Danev, R., Kooistra, A.J., Belousoff, M.J., Christopoulos, A., Truong, T.T. , provided free of copyright via the Protein DataBank. View original data or read license terms.
