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      PDB | 6wj5 Structure of human TRPA1

      Structure of human TRPA1 in complex with inhibitor GDC-0334

      label Keywords
      trpa1, channel, inhibitor, antagonist, membrane protein, membrane protein-inhibitor complex
      event_note Published
      05/29/2024
      filter_center_focus Method
      ELECTRON MICROSCOPY
      add_circle Ligands
      (4R,5S)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-({5-(trifluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl}methyl)-L-prolinamide

      Original publication

      import_contacts Title
      A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
      import_contacts Journal
      J.Exp.Med. 2021
      import_contacts DOI
      10.1084/jem.20201637
      person Authors
      Brillantes, B., Chernov-Rogan, T., Chen, Y., Villemure, E., Rohou, A., Jung, M., Lin, J.H., Estevez, A., Magnuson, S., Wu, X., Barck, K.H., Bauer, R.N., Ding, H.T., Gogineni, A., Bjornson, C., Liu, J., Bravo, D.D., Heredia, J.E., Volgraf, M., Verma, V.A., Chen, J., Shore, D.G.M., Safina, B.S., Chen, H., Zhang, J., Balestrini, A., Lee, W.P., Liu, L., Arthur, C.P., Leong, L., Chen, L., Doerr, J., Kortmann, J., Hu, B., Vander Heiden, J.A., Wong, R.L., Liederer, B.M., Tam, L., Rouge, L., Carano, R.A.D., Gao, S.S., Austin, C.D., Tam, C., Hackos, D.H., Wang, J., Ciferri, C., Payandeh, J., Reese, R.M., Wang, L., Riol-Blanco, L., Shields, S.D., Elstrott, J., Gandham, V., Suto, E., Joseph, V., Dourado, M., Roose-Girma, M., Hotzel, K., Ly, J.Q., Yang, X.

      Read article from J.Exp.Med.

      copyrightData provided by Research Collaboration for Structural Biology, Brillantes, B., Chernov-Rogan, T., Chen, Y., Villemure, E., Rohou, A., Jung, M., Lin, J.H., Estevez, A., Magnuson, S., Wu, X., Barck, K.H., Bauer, R.N., Ding, H.T., Gogineni, A., Bjornson, C., Liu, J., Bravo, D.D., Heredia, J.E., Volgraf, M., Verma, V.A., Chen, J., Shore, D.G.M., Safina, B.S., Chen, H., Zhang, J., Balestrini, A., Lee, W.P., Liu, L., Arthur, C.P., Leong, L., Chen, L., Doerr, J., Kortmann, J., Hu, B., Vander Heiden, J.A., Wong, R.L., Liederer, B.M., Tam, L., Rouge, L., Carano, R.A.D., Gao, S.S., Austin, C.D., Tam, C., Hackos, D.H., Wang, J., Ciferri, C., Payandeh, J., Reese, R.M., Wang, L., Riol-Blanco, L., Shields, S.D., Elstrott, J., Gandham, V., Suto, E., Joseph, V., Dourado, M., Roose-Girma, M., Hotzel, K., Ly, J.Q., Yang, X. , provided free of copyright via the Protein DataBank. View original data or read license terms.

      Simulations available

      play_circle_outline6wj5_default_dppc

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