PDB | 6w25 Melanocortin-4 Receptor (MC4R)
Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with SHU9119
label Keywords
melanocortin-4 receptor, ca++ cofactor, shu9119, gpcr, pgs fusion, membrane protein, lcp
event_note Published
03/04/2020
blur_on Resolution
2.75 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
CALCIUM ION, OLEIC ACID
Original publication
import_contacts Title
Determination of the melanocortin-4 receptor structure identifies Ca2+as a cofactor for ligand binding.
import_contacts Journal
Science 2020
import_contacts DOI
10.1126/science.aaz8995
person Authors
Zhao, S., Burdsall, K., Stauch, B., Williams, S.Y., Stevens, S.N., Wu, Y., Han, G.W., Peisley, A., Wein, A.H., Yu, J., Cone, R.D., Chen, V., McClary, K., Hernandez, C.C., Millhauser, G.L., Wu, L., Mittal, S.R., Gimenez, L.E., Stevens, R.C.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Zhao, S., Burdsall, K., Stauch, B., Williams, S.Y., Stevens, S.N., Wu, Y., Han, G.W., Peisley, A., Wein, A.H., Yu, J., Cone, R.D., Chen, V., McClary, K., Hernandez, C.C., Millhauser, G.L., Wu, L., Mittal, S.R., Gimenez, L.E., Stevens, R.C. , provided free of copyright via the Protein DataBank. View original data or read license terms.
