PDB | 6vcb Glucagon-like peptide-1 receptor
Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator
label Keywords
g protein-coupled receptor, membrane protein, family b gpcr, diabetes, allosteric modulator, signaling protein-membrane protein complex
event_note Published
10/23/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole
Original publication
import_contacts Title
Structural insights into probe-dependent positive allosterism of the GLP-1 receptor.
import_contacts Journal
Nat.Chem.Biol. 2020
import_contacts DOI
10.1038/s41589-020-0589-7
person Authors
Stutsman, C., Willard, F.S., Cumming, G.R., Vieth, M., Rojo, I., Wainscott, D.B., Sun, B., Bueno, A.B., Ho, J.D., Showalter, A.D., Agejas, F.J., Jimenez, A., Kobilka, T.S., Feng, D., Ficorilli, J., Chau, B., Chen, Q., Sloop, K.W., Kobilka, B.K.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Stutsman, C., Willard, F.S., Cumming, G.R., Vieth, M., Rojo, I., Wainscott, D.B., Sun, B., Bueno, A.B., Ho, J.D., Showalter, A.D., Agejas, F.J., Jimenez, A., Kobilka, T.S., Feng, D., Ficorilli, J., Chau, B., Chen, Q., Sloop, K.W., Kobilka, B.K. , provided free of copyright via the Protein DataBank. View original data or read license terms.
