PDB | 6rvd Human 2:1 Ptch1-Shh complex
Revised cryo-EM structure of the human 2:1 Ptch1-Shh complex
label Keywords
---- hedgehog morphogen receptor, receptor-nanobody complex, cholesterol, palmitate, lipid-protein-modification, membrane protein
event_note Published
11/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
CHOLESTEROL, 2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, ZINC ION, CALCIUM ION
Original publication
import_contacts Title
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
import_contacts Journal
Nat.Chem.Biol. 2019
import_contacts DOI
10.1038/s41589-019-0370-y
person Authors
Siebold, C., Malinauskas, T., Covey, D.F., Qian, M., Bishop, B., Rudolf, A.F., Wagner, A., Duman, R., Ansell, T.B., Kinnebrew, M., El Omari, K., Steyaert, J., Kowatsch, C., Rohatgi, R., Schwab, R.A., Sansom, M.S.P., Pardon, E.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Siebold, C., Malinauskas, T., Covey, D.F., Qian, M., Bishop, B., Rudolf, A.F., Wagner, A., Duman, R., Ansell, T.B., Kinnebrew, M., El Omari, K., Steyaert, J., Kowatsch, C., Rohatgi, R., Schwab, R.A., Sansom, M.S.P., Pardon, E. , provided free of copyright via the Protein DataBank. View original data or read license terms.
