PDB | 6rnk Humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91)
Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist NF-56-EJ40.
label Keywords
sucnr1, gpr91, gpcr, g-protein coupled receptor, nanobody, antagonist, succinate, complex, membrane protein
event_note Published
11/20/2024
blur_on Resolution
1.94 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
2-[2-[[3-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]phenyl]carbonylamino]phenyl]ethanoic acid, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GLYCEROL, SULFATE ION
Original publication
import_contacts Title
Structural basis of species-selective antagonist binding to the succinate receptor.
import_contacts Journal
Nature 2019
import_contacts DOI
10.1038/s41586-019-1663-8
person Authors
Gommermann, N., Rummel, G., Boivineau, J., Duckely, M., Freuler, F., Littlewood-Evans, A., Kaupmann, K., Sirockin, F., Fehlmann, D., Jaakola, V.P., Haffke, M., Cotesta, S.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Gommermann, N., Rummel, G., Boivineau, J., Duckely, M., Freuler, F., Littlewood-Evans, A., Kaupmann, K., Sirockin, F., Fehlmann, D., Jaakola, V.P., Haffke, M., Cotesta, S. , provided free of copyright via the Protein DataBank. View original data or read license terms.
