PDB | 6oz6 MraY bound to 3'-hydroxymureidomycin A
Crystal structure of MraY bound to 3'-hydroxymureidomycin A
label Keywords
peptidoglycan biosynthesis, antibiotic target, integral membrane enzyme, translocase, membrane protein, membrane protein-transferase complex
event_note Published
11/06/2024
blur_on Resolution
3.7 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
(2~{S})-2-[[(2~{S})-1-[[(2~{S},3~{S})-3-[[(2~{S})-2-azanyl-3-(3-hydroxyphenyl)propanoyl]-methyl-amino]-1-[[(~{Z})-[(3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-ylidene]methyl]amino]-1-oxidanylidene-butan-2-yl]amino]-4-methylsulfanyl-1-oxidanylidene-butan-2-yl]carbamoylamino]-3-(3-hydroxyphenyl)propanoic acid
Original publication
import_contacts Title
Chemical logic of MraY inhibition by antibacterial nucleoside natural products.
import_contacts Journal
Nat Commun 2019
import_contacts DOI
10.1038/s41467-019-10957-9
person Authors
Lee, K., Hong, J., Kaeser, B., Terasawa, Y., Mashalidis, E.H., Lee, S.Y., Ichikawa, S., Katsuyama, A., Kwon, D.Y.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Lee, K., Hong, J., Kaeser, B., Terasawa, Y., Mashalidis, E.H., Lee, S.Y., Ichikawa, S., Katsuyama, A., Kwon, D.Y. , provided free of copyright via the Protein DataBank. View original data or read license terms.
