PDB | 6ot0 Structure of human Smoothened-Gi complex

Structure of human Smoothened-Gi complex

label Keywords
gpcr, complex, hedgehog signaling, signaling protein
event_note Published
11/13/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL

Original publication

import_contacts Title
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.
import_contacts Journal
Nature 2019
import_contacts DOI
10.1038/s41586-019-1286-0
person Authors
Zhang, C., Liu, H., McDonald, J., Qi, X., Thompson, B., Li, X.

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