PDB | 6nv1 Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor
Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor
label Keywords
proton channel, membrane protein
event_note Published
10/23/2024
blur_on Resolution
2.5 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, CHLORIDE ION
Original publication
import_contacts Title
X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.
import_contacts Journal
Biochemistry 2020
import_contacts DOI
10.1021/acs.biochem.9b00971
person Authors
Wang, J., Kolocouris, A., Degrado, W.F., Thomaston, J.L., Konstantinidi, A., Tan, J., Lambrinidis, G., Caffrey, M., Liu, L.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Wang, J., Kolocouris, A., Degrado, W.F., Thomaston, J.L., Konstantinidi, A., Tan, J., Lambrinidis, G., Caffrey, M., Liu, L. , provided free of copyright via the Protein DataBank. View original data or read license terms.
