PDB | 6nt4 Human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2.
Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2.
label Keywords
sodium channel, scorpion toxin, electrical signaling, fast inactivation, membrane protein
event_note Published
05/28/2025
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
2-acetamido-2-deoxy-beta-D-glucopyranose, (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, Digitonin, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, CHOLESTEROL HEMISUCCINATE
Original publication
import_contacts Title
Structural basis of alpha-scorpion toxin action on Na v channels.
import_contacts Journal
Science 2019
import_contacts DOI
10.1126/science.aav8573
person Authors
Ciferri, C., Hackos, D.H., Bougis, P.E., Clairfeuille, T., Bosmans, F., Ahern, C.A., Infield, D.T., Rohou, A., Payandeh, J., Jian, Y., Li, Z.R., Cloake, A., Llongueras, J.P., Arthur, C.P., Martin-Eauclaire, M.F.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Ciferri, C., Hackos, D.H., Bougis, P.E., Clairfeuille, T., Bosmans, F., Ahern, C.A., Infield, D.T., Rohou, A., Payandeh, J., Jian, Y., Li, Z.R., Cloake, A., Llongueras, J.P., Arthur, C.P., Martin-Eauclaire, M.F. , provided free of copyright via the Protein DataBank. View original data or read license terms.
