PDB | 6me8 Human melatonin receptor MT2 (N86D)
XFEL crystal structure of human melatonin receptor MT2 (N86D) in complex with 2-phenylmelatonin
label Keywords
gpcr, melatonin receptor type 1b (mt2), n86d mutation, membrane protein, 2-phenylmelatonin, xfel, lcp, bril, rubredoxin, circadian rhythm, jetlag, type 2 diabetes
event_note Published
10/23/2024
blur_on Resolution
3.1 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, ZINC ION
Original publication
import_contacts Title
XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity.
import_contacts Journal
Nature 2019
import_contacts DOI
10.1038/s41586-019-1144-0
person Authors
Patel, N., Han, G.W., Zatsepin, N.A., Grandner, J.M., Yous, S., Stauch, B., Johansson, L.C., Li, C., Zhu, L., Roth, B.L., Katritch, V., McCorvy, J.D., Batyuk, A., Liu, W., Weierstall, U., Cherezov, V., Slocum, S.T., Hao, S., Huang, X.P., Zaare, S., Olsen, R.H.J., Gati, C., Tribo, A.R., Stevens, R.C.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Patel, N., Han, G.W., Zatsepin, N.A., Grandner, J.M., Yous, S., Stauch, B., Johansson, L.C., Li, C., Zhu, L., Roth, B.L., Katritch, V., McCorvy, J.D., Batyuk, A., Liu, W., Weierstall, U., Cherezov, V., Slocum, S.T., Hao, S., Huang, X.P., Zaare, S., Olsen, R.H.J., Gati, C., Tribo, A.R., Stevens, R.C. , provided free of copyright via the Protein DataBank. View original data or read license terms.
