PDB | 6lyy Human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate AZD3965 in the outward-open conformation.

Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate AZD3965 in the outward-open conformation.

label Keywords
proton-coupled monocarboxylate transporter, mct1, basigin, anti-cancer, azd3965, bay-8002, 7acc2, single particle cryo-em, latate transporter, transport protein
event_note Published
03/27/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
3-methyl-5-[[(4~{R})-4-methyl-4-oxidanyl-1,2-oxazolidin-2-yl]carbonyl]-6-[[5-methyl-3-(trifluoromethyl)-1~{H}-pyrazol-4-yl]methyl]-1-propan-2-yl-thieno[2,3-d]pyrimidine-2,4-dione

Original publication

import_contacts Title
Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
import_contacts Journal
Cell 2021
import_contacts DOI
10.1016/j.cell.2020.11.043
person Authors
Yuan, Y., Zhu, A., Lei, J., Yan, C., Xu, H., Jiang, X., Zhang, S., Wang, N.

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