PDB | 6lr4 Molecular basis for inhibition of human gamma-secretase by small molecule
Molecular basis for inhibition of human gamma-secretase by small molecule
label Keywords
inhibitor, membrane protein
event_note Published
07/02/2025
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide, CHOLESTEROL
Original publication
import_contacts Title
Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
import_contacts Journal
Cell 2021
import_contacts DOI
10.1016/j.cell.2020.11.049
person Authors
Yang, G., Shi, Y., Lei, J., Yan, C., Guo, X., Zhou, R.
copyrightData provided by Research Collaboration for Structural Biology, Yang, G., Shi, Y., Lei, J., Yan, C., Guo, X., Zhou, R. , provided free of copyright via the Protein DataBank. View original data or read license terms.
