PDB | 6lqg Human gamma-secretase
Human gamma-secretase in complex with small molecule Avagacestat
label Keywords
small molecule, membrane protein, membrane protein-hydrolase complex
event_note Published
10/09/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
2-acetamido-2-deoxy-beta-D-glucopyranose, (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoranyl-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-tris(fluoranyl)pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL
Original publication
import_contacts Title
Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
import_contacts Journal
Cell 2021
import_contacts DOI
10.1016/j.cell.2020.11.049
person Authors
Yang, G., Shi, Y., Lei, J., Yan, C., Guo, X., Zhou, R.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Yang, G., Shi, Y., Lei, J., Yan, C., Guo, X., Zhou, R. , provided free of copyright via the Protein DataBank. View original data or read license terms.
