PDB | 6huo Human full-length heteromeric alpha1beta3gamma2L GABA(A)R

CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with alprazolam (Xanax), GABA and megabody Mb38.

label Keywords
gabaar, membrane protein, plgic, cys-loop receptor
event_note Published
11/06/2024
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
GAMMA-AMINO-BUTANOIC ACID, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Original publication

import_contacts Title
GABAAreceptor signalling mechanisms revealed by structural pharmacology.
import_contacts Journal
Nature 2019
import_contacts DOI
10.1038/s41586-018-0832-5
person Authors
Uchanski, T., Masiulis, S., Malinauskas, T., Aricescu, A.R., Miller, K.W., Laverty, D., Zivanov, J., Karia, D., Kotecha, A., Steyaert, J., Pardon, E., Desai, R., Serna Martin, I.

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