PDB | 6huk Human full-length alpha1beta3gamma2L GABA(A)R
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38.
label Keywords
gabaar, membrane, channel, nanobody, megabody, cys-loop, plgic, inhibition, signalling, cns, neurons, chloride, ion, gaba, bcc, bicuculline, membrane protein, antagonist
event_note Published
10/08/2018
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
bicuculline methochloride, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Original publication
import_contacts Title
GABAAreceptor signalling mechanisms revealed by structural pharmacology.
import_contacts Journal
Nature 2019
import_contacts DOI
10.1038/s41586-018-0832-5
person Authors
Uchanski, T., Masiulis, S., Malinauskas, T., Aricescu, A.R., Miller, K.W., Laverty, D., Zivanov, J., Karia, D., Kotecha, A., Steyaert, J., Pardon, E., Desai, R., Serna Martin, I.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Uchanski, T., Masiulis, S., Malinauskas, T., Aricescu, A.R., Miller, K.W., Laverty, D., Zivanov, J., Karia, D., Kotecha, A., Steyaert, J., Pardon, E., Desai, R., Serna Martin, I. , provided free of copyright via the Protein DataBank. View original data or read license terms.
