PDB | 6hlo Neurokinin 1 receptor
Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Aprepitant
label Keywords
7-tm; gpcr; signalling protein, membrane protein
event_note Published
01/24/2024
blur_on Resolution
2.4 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, CITRIC ACID, OLEIC ACID, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Original publication
import_contacts Title
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.
import_contacts Journal
Nat Commun 2019
import_contacts DOI
10.1038/s41467-018-07939-8
person Authors
Dore, A.S., Klenk, C., Rucktooa, P., Schutz, M., Pluckthun, A., Ehrenmann, J., Schoppe, J.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Dore, A.S., Klenk, C., Rucktooa, P., Schutz, M., Pluckthun, A., Ehrenmann, J., Schoppe, J. , provided free of copyright via the Protein DataBank. View original data or read license terms.
