PDB | 6hij Human ABCG2-MZ29-Fab complex
Cryo-EM structure of the human ABCG2-MZ29-Fab complex with cholesterol and PE lipids docked
label Keywords
abc transporter, transport protein
event_note Published
08/30/2018
filter_center_focus Method
ELECTRON MICROSCOPY
add_circle Ligands
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, ~{tert}-butyl 3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate
Original publication
import_contacts Title
Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
import_contacts Journal
Nat.Struct.Mol.Biol. 2018
import_contacts DOI
10.1038/s41594-018-0049-1
person Authors
Bernhardt, G., Zechner, M., Buschauer, A., Bauer, S., Locher, K.P., Koenig, B., Jackson, S.M., Manolaridis, I., Kowal, J., Bause, M., Bartholomaeus, R., Altmann, K.H., Stahlberg, H., Taylor, N.M.I.
copyrightData provided by Research Collaboration for Structural Biology, Bernhardt, G., Zechner, M., Buschauer, A., Bauer, S., Locher, K.P., Koenig, B., Jackson, S.M., Manolaridis, I., Kowal, J., Bause, M., Bartholomaeus, R., Altmann, K.H., Stahlberg, H., Taylor, N.M.I. , provided free of copyright via the Protein DataBank. View original data or read license terms.
