PDB | 6haw Bovine cytochrome bc1
Crystal structure of bovine cytochrome bc1 in complex with 2-pyrazolyl quinolone inhibitor WDH2G7
label Keywords
cytochrome bc1, malaria, electron transport
event_note Published
01/17/2024
blur_on Resolution
3.45 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, TRIETHYLENE GLYCOL, PHOSPHATE ION, CARDIOLIPIN, TETRAETHYLENE GLYCOL, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE, DODECYL-BETA-D-MALTOSIDE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-methoxy-3-methyl-2-[1-[[4-(trifluoromethyloxy)phenyl]methyl]pyrazol-4-yl]-3~{H}-quinolin-4-one, HEME C, FE2/S2 (INORGANIC) CLUSTER, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Original publication
import_contacts Title
Potent Antimalarial 2-Pyrazolyl Quinolonebc1(Qi) Inhibitors with Improved Drug-like Properties.
import_contacts Journal
ACS Med Chem Lett 2018
import_contacts DOI
10.1021/acsmedchemlett.8b00371
person Authors
O'Neill, P.M., Davies, J., Berry, N.G., David Hong, W., Ward, S.A., Priestley, R.S., Biagini, G.A., Nixon, G.L., Antonyuk, S., Samar Hasnain, S., Leung, S.C., Amporndanai, K.
Member of
copyrightData provided by Research Collaboration for Structural Biology, O'Neill, P.M., Davies, J., Berry, N.G., David Hong, W., Ward, S.A., Priestley, R.S., Biagini, G.A., Nixon, G.L., Antonyuk, S., Samar Hasnain, S., Leung, S.C., Amporndanai, K. , provided free of copyright via the Protein DataBank. View original data or read license terms.
