PDB | 6gt3 A2A-StaR2-bRIL562
Crystal Structure of the A2A-StaR2-bRIL562 in complex with AZD4635 at 2.0A resolution
label Keywords
7tm, gpcr, signalling protein, membrane protein
event_note Published
10/23/2024
blur_on Resolution
2 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
SODIUM ION, 6-(2-chloranyl-6-methyl-pyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine, CHOLESTEROL, OLEIC ACID, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Original publication
import_contacts Title
Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity
import_contacts Journal
J Immunother Cancer 2020
import_contacts DOI
?
person Authors
Cheng, R.K.Y., Congreve, M., Linghu, B., Reimer, C., Brown, G.A., Brown, J., Wang, Y., Prickett, L., Woessner, R., Chandra, D., Clarke, J.D., Sachsenmeier, K., Barbon, C.M., Shaw, J., Fawell, S., Drew, L., Deng, N., Ye, M., Borodovsky, A., Shao, W., Hurrell, E., Schuller, A.G., Dore, A.S., Mele, D.A.
copyrightData provided by Research Collaboration for Structural Biology, Cheng, R.K.Y., Congreve, M., Linghu, B., Reimer, C., Brown, G.A., Brown, J., Wang, Y., Prickett, L., Woessner, R., Chandra, D., Clarke, J.D., Sachsenmeier, K., Barbon, C.M., Shaw, J., Fawell, S., Drew, L., Deng, N., Ye, M., Borodovsky, A., Shao, W., Hurrell, E., Schuller, A.G., Dore, A.S., Mele, D.A. , provided free of copyright via the Protein DataBank. View original data or read license terms.
