PDB | 5wqc Human orexin 2 receptor bound to the selective antagonist EMPA determined by the synchrotron light source at SPring-8.
Crystal structure of human orexin 2 receptor bound to the selective antagonist EMPA determined by the synchrotron light source at SPring-8.
label Keywords
g protein-coupled receptor, orexin neurotransmitters, orexin 2 receptor, orexin-a, orexin-b, empa, n-linked glycosylation, signaling protein
event_note Published
11/13/2024
blur_on Resolution
1.96 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, PENTAETHYLENE GLYCOL
Original publication
import_contacts Title
Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA
import_contacts Journal
Structure 2018
import_contacts DOI
10.1016/j.str.2017.11.005
person Authors
Kimura, K.T., Shimamura, T., Yamashita, K., Shimamoto, K., Rosenbaum, D.M., Joti, Y., Kameshima, T., Horita, S., Iwata, S., Fujiwara, T., Hatsui, T., Hirokawa, T., Yamanaka, Y., Nakane, T., Kobayashi, T., Tawaramoto, M.S., Wang, J., Im, D., Nango, E., Suno, R., Yabashi, M., Yamamoto, M., Tsujimoto, H., Tono, K.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Kimura, K.T., Shimamura, T., Yamashita, K., Shimamoto, K., Rosenbaum, D.M., Joti, Y., Kameshima, T., Horita, S., Iwata, S., Fujiwara, T., Hatsui, T., Hirokawa, T., Yamanaka, Y., Nakane, T., Kobayashi, T., Tawaramoto, M.S., Wang, J., Im, D., Nango, E., Suno, R., Yabashi, M., Yamamoto, M., Tsujimoto, H., Tono, K. , provided free of copyright via the Protein DataBank. View original data or read license terms.
