PDB | 5wf5 Agonist bound human A2a adenosine receptor
Agonist bound human A2a adenosine receptor with D52N mutation at 2.60 A resolution
label Keywords
human a2a adenosine receptor, d52n, gpcr-t4l chimera, membrane protein, lcp, agonist, uk432097, activation microswitch, allosteric na-site mutant, gpcr signaling
event_note Published
10/16/2024
blur_on Resolution
2.6 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Original publication
import_contacts Title
Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.
import_contacts Journal
Structure 2018
import_contacts DOI
10.1016/j.str.2017.12.013
person Authors
Deary, A., Lian, T., Gao, Z.G., White, K.L., Han, G.W., Katritch, V., Jacobson, K.A., Eddy, M.T., Stevens, R.C., Patel, N.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Deary, A., Lian, T., Gao, Z.G., White, K.L., Han, G.W., Katritch, V., Jacobson, K.A., Eddy, M.T., Stevens, R.C., Patel, N. , provided free of copyright via the Protein DataBank. View original data or read license terms.
