PDB | 5tzr GPR40 in complex with partial agonist MK-8666
GPR40 in complex with partial agonist MK-8666
label Keywords
ffar1, partial agonist, fatty acid binding protein-hydrolase complex
event_note Published
11/06/2024
blur_on Resolution
2.2 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
SODIUM ION, (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, MALONATE ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, PENTAETHYLENE GLYCOL
Original publication
import_contacts Title
Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
import_contacts Journal
Nat. Struct. Mol. Biol. 2017
import_contacts DOI
10.1038/nsmb.3417
person Authors
Weinglass, A.B., Ho, T., Patel, S.B., Soisson, S.M., Josien, H., Kornienko, M., Lu, J., Hermes, J.D., Souza, S., Sheth, P., Allen, S.J., Hastings, N.B., Johnston, J.M., Colletti, S.L., Brown, F.K., Guo, Y., Sharma, S., Tummala, S., Thomas-Fowlkes, B., Webb, M., Sherborne, B.S., Pio, B., Chobanian, H.R., Wang, J., Bricogne, G., Di Salvo, J., Hadix, J., Plummer, C.W., Lumb, K.J., Miller, M.W., Howard, A.D., Byrne, N., Vonrhein, C., Hall, D.L.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Weinglass, A.B., Ho, T., Patel, S.B., Soisson, S.M., Josien, H., Kornienko, M., Lu, J., Hermes, J.D., Souza, S., Sheth, P., Allen, S.J., Hastings, N.B., Johnston, J.M., Colletti, S.L., Brown, F.K., Guo, Y., Sharma, S., Tummala, S., Thomas-Fowlkes, B., Webb, M., Sherborne, B.S., Pio, B., Chobanian, H.R., Wang, J., Bricogne, G., Di Salvo, J., Hadix, J., Plummer, C.W., Lumb, K.J., Miller, M.W., Howard, A.D., Byrne, N., Vonrhein, C., Hall, D.L. , provided free of copyright via the Protein DataBank. View original data or read license terms.
