PDB | 5tl9 MPGES-1 bound to inhibitor
crystal structure of mPGES-1 bound to inhibitor
label Keywords
prostaglandin, enzyme, integral membrane protein, alpha helix, mpges1 - ligand 0, membrane protein, transferase
event_note Published
10/10/2016
blur_on Resolution
1.2 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
2-{2-[(1S,2S)-2-{[1-(8-methylquinolin-2-yl)piperidine-4-carbonyl]amino}cyclopentyl]ethyl}benzoic acid, GLUTATHIONE, hexyl beta-D-glucopyranoside, octyl beta-D-glucopyranoside, TETRAETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER
Original publication
import_contacts Title
Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
import_contacts Journal
Bioorg. Med. Chem. Lett. 2017
import_contacts DOI
10.1016/j.bmcl.2016.11.011
person Authors
Warshawsky, A.M., Schiffler, M.A., Navarro, A., Manninen, P.R., Harvey, A., Sloan, A.V., Yu, X.P., Fretland, A., Gooding, K., Weller, J.M., Chandrasekhar, S., Fisher, M.J., McGee, J.E., Quimby, S.J., Luz, J.G., York, J.S., Bhattachar, S.N., Antonysamy, S., Partridge, K.M., Norman, B.H., Mudra, D.R., Kuklish, S.L., Hughes, N.E.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Warshawsky, A.M., Schiffler, M.A., Navarro, A., Manninen, P.R., Harvey, A., Sloan, A.V., Yu, X.P., Fretland, A., Gooding, K., Weller, J.M., Chandrasekhar, S., Fisher, M.J., McGee, J.E., Quimby, S.J., Luz, J.G., York, J.S., Bhattachar, S.N., Antonysamy, S., Partridge, K.M., Norman, B.H., Mudra, D.R., Kuklish, S.L., Hughes, N.E. , provided free of copyright via the Protein DataBank. View original data or read license terms.
