PDB | 5t1a Structure of CC Chemokine Receptor 2
Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists
label Keywords
c-c chemokine receptor type 2, dual antagonist, intracellular allosteric antagonist, cooperative binding, lipidic cubic phase, membrane protein, gpcr, structural genomics, psi-2, protein structure initiative, gpcr network, signaling protein
event_note Published
08/18/2016
blur_on Resolution
2.806 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
(3S)-1-{(1S,2R,4R)-4-[methyl(propan-2-yl)amino]-2-propylcyclohexyl}-3-{[6-(trifluoromethyl)quinazolin-4-yl]amino}pyrrolidin-2-one, (2~{R})-1-(4-chloranyl-2-fluoranyl-phenyl)-2-cyclohexyl-3-ethanoyl-4-oxidanyl-2~{H}-pyrrol-5-one, SULFATE ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ZINC ION
Original publication
import_contacts Title
Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.
import_contacts Journal
Nature 2016
import_contacts DOI
10.1038/nature20605
person Authors
Zheng, Y., Stevens, R.C., Kufareva, I., Tebben, A., Qin, L., Zacarias, N.V., Han, G.W., de Vries, H., Zhao, C., Carter, P., Cherney, R.J., Heitman, L.H., Abagyan, R., Stamos, D., Handel, T.M., Dabros, M., Cherezov, V., Gustavsson, M., IJzerman, A.P.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Zheng, Y., Stevens, R.C., Kufareva, I., Tebben, A., Qin, L., Zacarias, N.V., Han, G.W., de Vries, H., Zhao, C., Carter, P., Cherney, R.J., Heitman, L.H., Abagyan, R., Stamos, D., Handel, T.M., Dabros, M., Cherezov, V., Gustavsson, M., IJzerman, A.P. , provided free of copyright via the Protein DataBank. View original data or read license terms.
