PDB | 5svq ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP

Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP

label Keywords
membrane protein, ion channel, antagonist state
event_note Published
11/13/2024
blur_on Resolution
3.25 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, MAGNESIUM ION, SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE

Original publication

import_contacts Title
X-ray structures define human P2X3 receptor gating cycle and antagonist action.
import_contacts Journal
Nature 2016
import_contacts DOI
10.1038/nature19367
person Authors
Lu, W., Mansoor, S.E., Tajkhorshid, E., Gouaux, E., Shekhar, M., Oosterheert, W.

Loading