PDB | 5svq ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP
Crystal structure of the ATP-gated human P2X3 ion channel bound to competitive antagonist TNP-ATP
label Keywords
membrane protein, ion channel, antagonist state
event_note Published
11/13/2024
blur_on Resolution
3.25 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, MAGNESIUM ION, SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE
Original publication
import_contacts Title
X-ray structures define human P2X3 receptor gating cycle and antagonist action.
import_contacts Journal
Nature 2016
import_contacts DOI
10.1038/nature19367
person Authors
Lu, W., Mansoor, S.E., Tajkhorshid, E., Gouaux, E., Shekhar, M., Oosterheert, W.
copyrightData provided by Research Collaboration for Structural Biology, Lu, W., Mansoor, S.E., Tajkhorshid, E., Gouaux, E., Shekhar, M., Oosterheert, W. , provided free of copyright via the Protein DataBank. View original data or read license terms.