PDB | 5o5e Human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant)
Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) in complex with tunicamycin
label Keywords
protein glycosylation, integral membrane protein, pnpt, congenital myasthenic syndrome, antibiotic, structural genomics, structural genomics consortium, sgc, transferase
event_note Published
05/08/2024
blur_on Resolution
3.4 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
(2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Tunicamycin, UNKNOWN LIGAND
Original publication
import_contacts Title
Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.
import_contacts Journal
Cell 2018
import_contacts DOI
10.1016/j.cell.2018.10.037
person Authors
Park, Y., Belaya, K., Liu, W.W., Chu, A., Robinson, C.V., Carpenter, E.P., Cochrane, S.A., Royer, S.F., Wyszynski, F.J., Machida, T., Chalk, R., Lee, S.S., Hamedzadeh, S., Sajid, A., Widdick, D.A., Dong, Y.Y., Liu, W.M., Shrestha, L., Strain-Damerell, C., Lucas, R., Bibb, M.J., Pike, A.C.W., Beeson, D., Burgess-Brown, N.A., Minall, L., Wang, H., Bushell, S.R., Boshoff, H.I., Barry Iii, C.E., Mehmood, S., Davis, B.G., Mukhopadhyay, S.M.M.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Park, Y., Belaya, K., Liu, W.W., Chu, A., Robinson, C.V., Carpenter, E.P., Cochrane, S.A., Royer, S.F., Wyszynski, F.J., Machida, T., Chalk, R., Lee, S.S., Hamedzadeh, S., Sajid, A., Widdick, D.A., Dong, Y.Y., Liu, W.M., Shrestha, L., Strain-Damerell, C., Lucas, R., Bibb, M.J., Pike, A.C.W., Beeson, D., Burgess-Brown, N.A., Minall, L., Wang, H., Bushell, S.R., Boshoff, H.I., Barry Iii, C.E., Mehmood, S., Davis, B.G., Mukhopadhyay, S.M.M. , provided free of copyright via the Protein DataBank. View original data or read license terms.
