PDB | 5ndz Thermostabilised human protease-activated receptor-2 (PAR2)
Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ3451 at 3.6 angstrom resolution
label Keywords
membrane protein, gpcr, 7tm
event_note Published
10/16/2024
blur_on Resolution
3.6 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide, SODIUM ION
Original publication
import_contacts Title
Structural insight into allosteric modulation of protease-activated receptor 2.
import_contacts Journal
Nature 2017
import_contacts DOI
10.1038/nature22309
person Authors
Cheng, R.K.Y., Jazayeri, A., Dekker, N., Zhukov, A., Cooke, R.M., Rappas, M., Brown, G.A., Aggeler, B., Prihandoko, R., Geschwindner, S., Brown, D.G., Johansson, P., Soutter, H., Leong, L., Dumelin, C.E., Edman, K., Snijder, A., Troast, D., Hermansson, N.O., Grebner, C., Fiez-Vandal, C., Dore, A.S., Schlenker, O., Marshall, F.H., Tehan, B., Sundstrom, L., Wiggin, G., Thornton, P.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Cheng, R.K.Y., Jazayeri, A., Dekker, N., Zhukov, A., Cooke, R.M., Rappas, M., Brown, G.A., Aggeler, B., Prihandoko, R., Geschwindner, S., Brown, D.G., Johansson, P., Soutter, H., Leong, L., Dumelin, C.E., Edman, K., Snijder, A., Troast, D., Hermansson, N.O., Grebner, C., Fiez-Vandal, C., Dore, A.S., Schlenker, O., Marshall, F.H., Tehan, B., Sundstrom, L., Wiggin, G., Thornton, P. , provided free of copyright via the Protein DataBank. View original data or read license terms.
