PDB | 5l7d Structure of human Smoothened
Structure of human Smoothened in complex with cholesterol
label Keywords
g protein coupled receptor, morphogen signaling, hedgehog signaling, cholesterol, signaling protein, membrane protein
event_note Published
11/20/2024
blur_on Resolution
3.2 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, SODIUM ION
Original publication
import_contacts Title
Structural basis of Smoothened regulation by its extracellular domains.
import_contacts Journal
Nature 2016
import_contacts DOI
10.1038/nature18934
person Authors
Siebold, C., Sansom, M.S., Sircar, R., Nachtergaele, S., Covey, D.F., Rambo, R.P., Hedger, G., Newstead, S., Luchetti, G., Byrne, E.F., Miller, P.S., Mydock-McGrane, L., Tully, M.D., Rohatgi, R.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Siebold, C., Sansom, M.S., Sircar, R., Nachtergaele, S., Covey, D.F., Rambo, R.P., Hedger, G., Newstead, S., Luchetti, G., Byrne, E.F., Miller, P.S., Mydock-McGrane, L., Tully, M.D., Rohatgi, R. , provided free of copyright via the Protein DataBank. View original data or read license terms.
