PDB | 5l4h 2-22' locally-closed mutant of GLIC
X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (brominated barbiturate)
label Keywords
membrane protein, transport protein
event_note Published
10/16/2024
blur_on Resolution
3.3 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
CHLORIDE ION, DODECYL-BETA-D-MALTOSIDE, 5-(2-bromoethyl)-5-ethyl-1,3-diazinane-2,4,6-trione
Original publication
import_contacts Title
Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.
import_contacts Journal
J. Biol. Chem. 2017
import_contacts DOI
10.1074/jbc.M116.766964
person Authors
Koehl, P., Ruza, R.R., Fourati, Z., Joseph, D., Delarue, M., Laverty, D., Smart, T., Drege, E., Delarue-Cochin, S.
copyrightData provided by Research Collaboration for Structural Biology, Koehl, P., Ruza, R.R., Fourati, Z., Joseph, D., Delarue, M., Laverty, D., Smart, T., Drege, E., Delarue-Cochin, S. , provided free of copyright via the Protein DataBank. View original data or read license terms.
