PDB | 5iu8 Stabilized A2A adenosine receptor A2AR-StaR2-bRIL
Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 12f at 2.0A resolution
label Keywords
g-protein-coupled receptor, integral membrane protein, chimera, thermostabilizing mutationsm, membrane protein
event_note Published
11/13/2024
blur_on Resolution
2.002 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
SODIUM ION, 2-(furan-2-yl)-N~5~-[2-(4-methylpiperazin-1-yl)ethyl][1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine, HEPTANE-1,2,3-TRIOL, CHOLESTEROL, OLEIC ACID, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Original publication
import_contacts Title
Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength.
import_contacts Journal
J.Med.Chem. 2016
import_contacts DOI
10.1021/acs.jmedchem.6b00653
person Authors
Cheng, R.K., Deflorian, F., Dore, A.S., Guo, D., Errey, J.C., Bortolato, A., Marshall, F.H., IJzerman, A.P., Segala, E., Heitman, L.H., Cooke, R.M.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Cheng, R.K., Deflorian, F., Dore, A.S., Guo, D., Errey, J.C., Bortolato, A., Marshall, F.H., IJzerman, A.P., Segala, E., Heitman, L.H., Cooke, R.M. , provided free of copyright via the Protein DataBank. View original data or read license terms.
