PDB | 5hs1 Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) complexed

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) complexed with Voriconazole

label Keywords
voriconazole, cyp51, oxidoreductase-oxidoreducatse inhibitor complex, resistance mutation, oxidoreductase-oxidoreductase inhibitor complex
event_note Published
01/24/2016
blur_on Resolution
2.1 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
PROTOPORPHYRIN IX CONTAINING FE, Voriconazole

Original publication

import_contacts Title
Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase.
import_contacts Journal
Sci Rep 2016
import_contacts DOI
10.1038/srep26213
person Authors
Tyndall, J.D., Wilson, R.K., Monk, B.C., Sagatova, A.A., Sabherwal, M., Keniya, M.V.

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