PDB | 5eqb Lanosterol 14-alpha demethylase
Crystal structure of lanosterol 14-alpha demethylase with intact transmembrane domain bound to itraconazole
label Keywords
sterol antifungal membrane cytochrome, structural genomics, psi-2, protein structure initiative, center for structures of membrane proteins, csmp, oxidoreductase-oxidoreductase inhibitor complex
event_note Published
03/06/2024
blur_on Resolution
2.19 Å
filter_center_focus Method
X-RAY DIFFRACTION
add_circle Ligands
PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Original publication
import_contacts Title
Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.
import_contacts Journal
Proc.Natl.Acad.Sci.USA 2014
import_contacts DOI
10.1073/pnas.1324245111
person Authors
Tyndall, J.D., Monk, B.C., O'Connell, J.D., Rodriguez, A., Finer-Moore, J.S., Huschmann, F.U., Stroud, R.M., Cannon, R.D., Tomasiak, T.M., McDonald, J.G., Keniya, M.V.
Member of
copyrightData provided by Research Collaboration for Structural Biology, Tyndall, J.D., Monk, B.C., O'Connell, J.D., Rodriguez, A., Finer-Moore, J.S., Huschmann, F.U., Stroud, R.M., Cannon, R.D., Tomasiak, T.M., McDonald, J.G., Keniya, M.V. , provided free of copyright via the Protein DataBank. View original data or read license terms.
